Drug intelligence / Profile preview

arctium lappa flavone extract

Development stage
Preclinical
Lead developer
Shenyang Agricultural University
Modality
Small Molecules
Administration
Oral
01

Overview

Arctium lappa flavone extract is a bioactive fraction derived from the roots of *Arctium lappa* (commonly known as Burdock), specifically processed to enrich for flavonoid content. This extract has been primarily investigated for its potential in treating atherosclerosis and hyperlipidemia. Research, particularly in avian models like quails, suggests that the flavone extract possesses significant antioxidant properties, enhancing the activity of endogenous enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) while reducing lipid peroxidation markers like malondialdehyde (MDA). Additionally, it demonstrates lipid-lowering effects by reducing serum total cholesterol, triglycerides, and low-density lipoprotein cholesterol (LDL-C), thereby exerting a protective effect against high-fat diet-induced vascular damage and plaque formation.

Other names
Burdock root flavone extractArctium lappa root flavone extract
02

Targets

GPX4 (Glutathione peroxidase 4)Misfolded SOD1

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