argifin

Argifin is a synthetic oligopeptide and a potent chitinase inhibitor originally isolated from soil microorganisms. It acts as a sub-nanomolar inhibitor of several chitinases including those from Serratia marcescens (SmChiA and SmChiB), Aspergillus fumigatus (chitinase B1), and human chitotriosidase. Argifin has demonstrated IC50 values in the low micromolar to nanomolar range for these targets. Its primary mechanism is competitive inhibition of chitinases by binding to their active sites. Argifin is considered an experimental compound with no current clinical indications or approvals[1][3][7][9].

Other names

243975-37-3(2R,5S,8S,11S,15S)-5-[3-[[amino-(methylcarbamoylamino)methylidene]amino]propyl]-8-benzyl-2,7-dimethyl-3,6,9,13,17-pentaoxo-1,4,7,10,14-pentazacycloheptadecane-11,15-dicarboxylic acid