arginase

Arginase is a manganese-dependent metalloenzyme of the urea cycle that catalyzes the hydrolysis of L-arginine to L-ornithine and urea. As a therapeutic agent, arginase is developed in two primary clinical contexts: as an enzyme replacement therapy (such as pegzilarginase) to treat arginase 1 deficiency (hyperargininemia), and as an arginine-depleting antineoplastic therapy (such as PEG-BCT-100) to treat arginine-auxotrophic cancers (including hepatocellular carcinoma, acute myeloid leukemia, and other solid tumors). By depleting systemic L-arginine, therapeutic arginase starves cancer cells that lack the ability to synthesize arginine de novo due to deficient expression of argininosuccinate synthetase (ASS1) or ornithine transcarbamylase (OTC).

Brand names

Loargys

Other names

L-arginaseL-arginine amidinohydrolasearginasearginase 1arginase1arginase-1arginase Iarginine amidinasecanavanase