Drug intelligence / Profile preview

arginine

Development stage
Approved
Lead developer
Ajinomoto
Modality
Peptides, Small Molecules, Recombinant Proteins and Enzymes
Administration
Oral, Intravenous
01

Overview

Arginine is a semi-essential amino acid that plays a key role in protein synthesis and various metabolic processes. In the body it is converted to nitric oxide by nitric oxide synthase; nitric oxide acts as a vasodilator by relaxing blood vessels and improving blood flow[6][8]. Arginine also stimulates the release of growth hormone and insulin[6][8]. It is used clinically as an intravenous diagnostic agent to assess pituitary function (growth hormone stimulation test) and as an oral or parenteral nutritional supplement for patients requiring additional protein intake or with specific metabolic needs[4][5]. It has been studied for cardiovascular conditions such as angina pectoris and hypertension; erectile dysfunction; peripheral arterial disease; pre-eclampsia; necrotizing enterocolitis in premature infants; male infertility; immune support in critical illness or after surgery; wound healing support; kidney function post-transplantation[6][8][10].

Brand names
L-ArginineR-Gene 10R-Gene10R-Gene-10Aminosyn II 7 %Aminosyn-PF 7%Clinimix 2.75/5Clinimix E 2.75/5Cinisol 15Cinisol15Cinisol-15Freamine 6.9Freamine6.9Freamine-6.9Freamine III 10Hepatamine 8Hepatamine8Hepatamine-8OlimelPeriolimelPlenaminePremasolPrimeneProcalamine 3Procalamine3Procalamine-3ProsolTravasol 10Travasol10Travasol-10Trophamine 10 %
Other names
L-arginine monohydrochlorideArginine Hydrochloride (USP)ArgiveneDetoxarginLevargin[7][9]
02

Targets

IR (Imidazoline receptor)NOS1 (nNOS)ADRA2A (α2A)

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