Drug intelligence / Profile preview

arginine + nicotinamide + niacin

Development stage
Unknown
Modality
Small Molecules, Drug Delivery Systems
Administration
Oral
01

Overview

This is a combination of three compounds—arginine, nicotinamide (also known as niacinamide), and niacin (nicotinic acid)—each with distinct biological roles. Arginine is an amino acid that serves as a precursor for nitric oxide, promoting vasodilation and supporting cardiovascular health. Nicotinamide and niacin are both forms of vitamin B3; they function as precursors to NAD/NADP, essential coenzymes in cellular metabolism. Niacin has additional lipid-lowering effects by modulating lipid metabolism through targets such as β-chain ATP synthase, ABCA1, and DGAT2. The combination may be used in dietary supplements aimed at supporting cardiovascular health by improving blood flow (via arginine) and lipid profiles (via niacin/niacinamide), with potential synergistic antioxidant effects[4][5][8].

02

Targets

HCAR2 (Hydroxycarboxylic acid receptor 2)NOS1 (nNOS)PARP1 (Poly (adp-ribose) polymerase 1)ABCA1 (ATP-binding cassette transporter A1)ATP5B (Mitochondrial F1-ATPase)DGAT2 (Hepatic diacylglycerol acyltransferase 2)NAD (Nicotinamide adenine dinucleotide)NO2- (Nitrite)

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