arginine + carvedilol

**Arginine + carvedilol** is a combination product containing two active substances: L-arginine, a conditionally essential amino acid involved in nitric oxide (NO) synthesis, and carvedilol, a non-selective beta-adrenergic and alpha-1 adrenergic receptor antagonist (beta-blocker). This combination has been explored for potential synergistic effects in cardiovascular disease, particularly for *hypertension*, *left ventricular dysfunction*, and *heart failure*, as well as for reducing peptic ulcer severity and oxidative stress in experimental models. Arginine increases endogenous NO (vasodilator, gastroprotectant) and carvedilol reduces blood pressure and heart rate by blocking adrenergic receptors. The exact clinical efficacy and approval status of this specific combination is limited; one formulation under the brand HYPERTENEVIDE-12.5 was marketed by Physician Therapeutics in the US as an unapproved kit.

Brand names

HYPERTENEVIDE-12.5HYPERTENEVIDE12.5HYPERTENEVIDE 12.5

Other names

arginine and carvedilol