Drug intelligence / Profile preview

arginine aspartate

Development stage
Phase 2
Modality
Small Molecules
Administration
Oral
01

Overview

**Arginine aspartate** is a 1:1 salt of L-arginine and L-aspartic acid used in oral medicinal products, including Asparten and Sargenor. The arginine component serves as a metabolic substrate, including for nitric oxide synthase-mediated nitric oxide production, while aspartate participates in intermediary metabolism. It has been used in products for temporary fatigue or asthenia and was evaluated as an oral pharmacological-chaperone strategy for p.Q188R homozygous classic galactosemia. In a completed four-participant pilot study, arginine aspartate did not improve galactose oxidation or rescue the deleterious p.Q188R galactose-1-phosphate uridylyltransferase phenotype. ([pmc.ncbi.nlm.nih.gov](https://pmc.ncbi.nlm.nih.gov/articles/PMC6260575/))

Brand names
AspartenSargenor
Other names
L-arginine L-aspartateL-arginine, L-aspartatearginine L-aspartate
02

Targets

NOS1 (nNOS)

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