arginine glutamate

**Arginine glutamate** is a 1:1 amino-acid salt of L-arginine and L-glutamic acid administered as an intravenous injection for adjunctive management of hyperammonemia associated with chronic liver disease. Following intravenous administration, it dissociates into arginine and glutamic acid. Its ammonia-lowering activity is attributed to support of hepatic nitrogen disposal, including increased hepatic arginase activity and provision of arginine for urea-cycle ammonia detoxification. Chinese post-marketing clinical research has evaluated arginine glutamate injection in cirrhosis-associated mild hepatic encephalopathy versus L-ornithine-L-aspartate, with reported noninferiority for clinical improvement, ammonia reduction, and number connection test improvement. ([m-pharma.com.cn](https://www.m-pharma.com.cn/uploads/%E8%AF%B4%E6%98%8E%E4%B9%A6/11.%20%E7%B2%BE%E6%B0%A8%E9%85%B8%E8%B0%B7%E6%B0%A8%E9%85%B8%E6%B3%A8%E5%B0%84%E6%B6%B2%E8%AF%B4%E6%98%8E%E4%B9%A6.pdf))

Brand names

思瑞雪

Other names

L-arginine L-glutamatearginine glutamate saltglutamate arginine