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arginine vasotocin
- Development stage
- Unknown
- Modality
- Peptides
- Administration
- Intranasal
01
Overview
Arginine vasotocin (AVT) is a naturally occurring nonapeptide hormone produced in the pineal gland of non-mammalian vertebrates and found in the mammalian pineal gland during fetal development and adulthood. Structurally, it is an evolutionary precursor and hybrid of oxytocin and arginine vasopressin, containing the cyclic ring of oxytocin and the side chain of vasopressin. AVT plays a significant role in the regulation of circadian rhythms and endocrine function. Clinical research has demonstrated that intranasal administration of AVT can dramatically increase REM sleep and decrease REM sleep latency in patients with narcolepsy, suggesting its involvement in the induction and organization of sleep cycles. While it has been investigated for sleep disorders and neurodevelopmental conditions like autism, it remains primarily an experimental substance rather than a widely marketed pharmaceutical.
- Other names
- vasotocin8-arginine-vasotocinArg-vasotocin
02
Targets
Oxytocin receptorAVPR2 (Arginine vasopressin V2 receptor)AVPR1B (Vasopressin V1b Receptor)AVPR1A (Arginine vasopressin receptor 1A)
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