argyrin F

Argyrin F is a macrocyclic peptide natural product derived from the myxobacterium *Archangium gephyra*. It functions as a potent inhibitor of the 20S proteasome, which leads to the stabilization and accumulation of the cyclin-dependent kinase inhibitor p27kip1. This accumulation induces cell cycle arrest in the G1 phase and promotes apoptosis in various cancer cells. In preclinical research, particularly for glioblastoma, Argyrin F has shown efficacy in reducing tumor growth and enhancing the infiltration of CD8+ T cells. It is also being investigated in combination with PD-1 checkpoint inhibitors to overcome therapeutic resistance in aggressive glioma models by modulating the tumor immunopeptidome and increasing cellular toxicity.