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Drug intelligence / Profile preview
aripiprazole
- Development stage
- Approved
- Lead developer
- Otsuka Pharmaceutical
- Modality
- Small Molecules
- Administration
- Intramuscular, Oral
01
Overview
Aripiprazole is an atypical antipsychotic (second-generation antipsychotic) used to treat a range of psychiatric disorders, including schizophrenia, bipolar I disorder, major depressive disorder (as adjunctive therapy), irritability associated with autism spectrum disorder, and Tourette's syndrome. It acts as a partial agonist at dopamine D2 and serotonin 5‑HT1A receptors and as an antagonist at serotonin 5‑HT2A receptors. This unique mechanism is thought to stabilize dopamine and serotonin activity in the brain, improving symptoms of psychosis, mood disturbances, and behavioral dysregulation. Aripiprazole was originally developed by Otsuka Pharmaceutical[5][6].
- Brand names
- AbilifyAbilify MaintenaAristadaAbilify AsimtufiiMezofyOpipzaAbilify DiscmeltAbilify Mycite
- Other names
- Aripiprazolum
02
Targets
ADRA1A (α1A)DRD2 (Dopamine D2 Receptor)DRD3 (Dopamine receptor D3)HRH1 (Histamine H1 Receptor)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))HTR2A (Serotonin receptor 5-HT2A)HTR2B (5-Hydroxytryptamine Receptor 2B)HTR2C (5-hydroxytryptamine 2C receptor)HTR7 (5-hydroxytryptamine receptor 7)SERT (Sodium-dependent serotonin transporter)
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