Drug intelligence / Profile preview

aripiprazole lauroxil

Development stage
Approved
Lead developer
Alkermes
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
Administration
Intramuscular
01

Overview

Aripiprazole lauroxil is a long-acting injectable atypical antipsychotic used for the treatment of schizophrenia in adults. It is a prodrug of aripiprazole, meaning it is converted in the body to its active form, aripiprazole. The drug acts primarily as a partial agonist at dopamine D2 and serotonin 5-HT1A receptors and as an antagonist at serotonin 5-HT2A receptors. This pharmacological profile helps rebalance dopamine and serotonin activity in the brain, improving symptoms such as delusions, hallucinations, thought disorders, social withdrawal, and emotional flattening associated with schizophrenia. Aripiprazole lauroxil was developed by Alkermes and is administered via intramuscular injection every four to eight weeks[4][5][7].

Brand names
AristadaAristada Initio
Other names
aripiprazole lauroxil
02

Targets

DRD3 (Dopamine receptor D3)HTR2A (Serotonin receptor 5-HT2A)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))DRD2 (Dopamine D2 Receptor)

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