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Aristada Initio

Development stage
Approved
Lead developer
Alkermes
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
Administration
Intramuscular
01

Overview

Aristada Initio is an extended-release injectable suspension containing aripiprazole lauroxil, a prodrug of aripiprazole. It is specifically formulated for single-use administration to initiate or re-initiate treatment with the long-acting antipsychotic, Aristada, in adults with schizophrenia. The mechanism of action involves partial agonism at dopamine D2 and serotonin 5-HT1A receptors and antagonism at serotonin 5-HT2A receptors. This pharmacological profile classifies it as an atypical antipsychotic. Aristada Initio is not intended for repeated dosing and must be used in combination with a single dose of oral aripiprazole and the first dose of Aristada to rapidly achieve therapeutic levels when starting or restarting long-acting therapy[4][7][8][10].

Brand names
Aristada Initio
Other names
aripiprazole lauroxil extended-release injectable suspension (initiation formulation)
02

Targets

DRD2 (Dopamine D2 Receptor)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))HTR2A (Serotonin receptor 5-HT2A)DRD3 (Dopamine receptor D3)

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