Drug intelligence / Profile preview

ARIZ-PRDM1-siRNA

Development stage
Preclinical
Lead developer
ARIZ Precision Medicine
Modality
Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Nanoparticles → Drug Delivery Systems
01

Overview

ARIZ Precision Medicine-PRDM1-siRNA-Colon Cancer is an experimental RNA interference (RNAi) therapeutic being developed by ARIZ Precision Medicine for the treatment of colon cancer. The drug consists of a small interfering RNA (siRNA) designed to knock down the expression of PRDM1 (PR domain zinc finger protein 1, also known as BLIMP-1), an epigenetic regulator and transcription factor that plays a critical role in cancer development and progression. The siRNA is delivered using ARIZ's proprietary Targeted Drug Delivery System (T-DDS), which utilizes nanoparticle technology to specifically target cancer cells. The program is currently in the early stages of development, ranging from target identification to proof-of-principle in the T-DDS platform.

Other names
PRDM1-siRNA (Colon Cancer)ARIZ Colon Cancer ProgramARIZ Precision Medicine-PRDM1-siRNA-Colon Cancer
02

Targets

PRDM1 (PR domain zinc finger protein 1)

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