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arsenic hexoxide
- Development stage
- Unknown
- Lead developer
- Chemas
- Modality
- Small Molecules
- Administration
- Intravenous, Oral
01
Overview
Arsenic hexoxide (As4O6) is an inorganic polymorphic arsenic compound developed by Chemas as an anticancer therapeutic. Originally derived from the natural mineral Sinsuk through a specialized purification process designed to eliminate toxicity, arsenic hexoxide exhibits potent antitumor activity across various malignancies, including cervical, bladder, brain, breast, colon, and non-small cell lung cancers. Its mechanism of action involves the induction of programmed cell death, G2/M cell cycle arrest, and autophagy. Specifically, arsenic hexoxide inhibits STAT3 phosphorylation, leading to mitochondrial reactive oxygen species (ROS) generation and caspase-3-dependent cleavage of gasdermin E (GSDME), which triggers pyroptosis in triple-negative breast cancer (TNBC) cells. It also suppresses the activation of Akt and VEGFR2, and downregulates NF-κB activity, thereby inhibiting angiogenesis, cell proliferation, and metastasis.
- Brand names
- TetraAS
- Other names
- tetra-arsenic hexoxidetetraarsenic hexoxidetetraarsenic oxide
02
Targets
AKT (RAC-alpha serine/threonine-protein kinase)STAT3 (Signal Transducer and Activator of Transcription 3)NF-κBVEGFR2 (Vascular endothelial growth factor receptor 2)GSDME (Gasdermin E)CASP3 (Caspase-3)
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