arsinothricin

Arsinothricin is a **small molecule organoarsenical antibiotic** and non-proteinogenic amino acid analog of glutamate originally identified as a natural product of *Burkholderia gladioli*. It is reported to act as a **broad-spectrum anti-infective** by **competitively inhibiting bacterial glutamine synthetase**, leading to suppression of nitrogen metabolism and bacterial growth. Preclinical publications describe activity against both Gram-positive and Gram-negative organisms, including multidrug-resistant bacteria such as carbapenem-resistant *Enterobacter cloacae*, *Escherichia coli*, and *Mycobacterium tuberculosis*, and also report activity against *Plasmodium falciparum*. The program appears to remain in the **research or preclinical stage**, with no identified commercial brand name and patenting activity associated with Florida International University.

Other names

arsinothricin