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ART12.11
- Development stage
- Preclinical
- Lead developer
- Artelo Biosciences
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
**ART12.11** is Artelo Biosciences' proprietary oral crystalline cocrystal composition of cannabidiol and tetramethylpyrazine. The candidate is designed to improve cannabidiol solubility, stability, and systemic exposure relative to conventional cannabidiol formulations. In rodent chronic-stress models, oral ART12.11 produced antidepressant-like and anxiolytic-like effects that exceeded cannabidiol alone, tetramethylpyrazine alone, and a noncrystalline cannabidiol plus tetramethylpyrazine mixture. It is being developed for depressive and anxiety disorders, with human studies planned but not confirmed as initiated in public sources.
- Other names
- CBD:TMP cocrystalcannabidiol:tetramethylpyrazine cocrystal
02
Targets
CNR1 (Cannabinoid receptor 1)CaV (Voltage-gated calcium channel protein complex)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))
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