artemether + lumefantrine + efavirenz

This represents a drug interaction scenario rather than a single formulated product. Artemether-lumefantrine is an antimalarial combination therapy used for acute uncomplicated malaria caused by Plasmodium falciparum, while efavirenz is an antiretroviral medication used in HIV treatment. When co-administered, efavirenz (a CYP3A4 inducer) significantly reduces plasma concentrations of artemether, its active metabolite dihydroartemisinin (DHA), and lumefantrine, potentially compromising antimalarial efficacy. Day 7 lumefantrine levels, considered predictive of treatment success, are reduced by approximately 46% with efavirenz co-administration.

Brand names

CoartemSustivaStocrin

Other names

artemether-lumefantrine and efavirenz