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artemisia afra
- Development stage
- Unknown
- Lead developer
- King Faisal Specialist Hospital and Research Centre
- Modality
- Small Molecules
- Administration
- Oral, Inhalation
01
Overview
African wormwood (*Artemisia afra*) is a perennial woody shrub native to Southern and Eastern Africa, widely utilized in traditional medicine for treating respiratory infections, fever, and malaria. Unlike its relative *Artemisia annua*, it contains only trace amounts of artemisinin, yet it exhibits significant antimalarial activity through artemisinin-independent pathways, notably by disrupting the lipid metabolism of *Plasmodium falciparum*. Currently, it is being evaluated in Phase 2 clinical trials for its ability to clear asymptomatic malaria reservoirs and inhibit gametocyte transmission. Beyond its antimalarial profile, *A. afra* extracts have demonstrated in vitro potential against *Mycobacterium tuberculosis* and the SARS-CoV-2 virus by inhibiting the 3CL protease and the spike protein's binding to ACE2 receptors.
- Other names
- African wormwoodumhlonyaneWilde-alslenganaArtemisia afra Jacq. ex Willd
02
Targets
FabI (Enoyl-acyl carrier protein reductase FabI)FabZ (3-hydroxyacyl-ACP dehydratase FabZ)
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