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artemisia capillaris aqueous extract
- Development stage
- Preclinical
- Lead developer
- Northeast Agricultural University
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Artemisia capillaris aqueous extract (AEAC) is a botanical extract derived from the aerial parts of *Artemisia capillaris* Thunb. or *Artemisia scoparia*. It is a complex mixture of bioactive compounds, including coumarins (such as capillarisin and esculetin), flavonoids, and organic acids. AEAC is primarily studied for its hepatoprotective, anti-inflammatory, and metabolic effects. Its mechanism of action involves the modulation of several signaling pathways, including NF-κB, AMPK, PI3K/AKT, and SREBP-1c, as well as the restoration of Glycine N-methyltransferase (GNMT) activity. Research indicates potential therapeutic applications in non-alcoholic fatty liver disease (NAFLD), obesity, alcoholic liver injury, and vascular dysfunction associated with diabetes.
- Other names
- InJinArtemisia capillaris extractaqueous extract of Artemisia capillaris
02
Targets
AMPK (Adenosine monophosphate–activated protein kinase)JNK (Mitogen-activated protein kinase kinase kinase family)Sir2p (Sir2 protein)SREBP-1 / SREBF1 (SREBP-1)GNMT (Glycine N-methyltransferase)
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