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artemisia capillaris ethyl acetate extract

Development stage: Preclinical
Modality: Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration: Oral

Overview

Artemisia capillaris ethyl acetate extract is a botanical research compound derived from the plant *Artemisia capillaris* Thunberg, commonly known as capillary wormwood. It is primarily investigated for its therapeutic potential in liver diseases and metabolic disorders. The extract contains several bioactive polyphenols and coumarins, including chlorogenic acid, scopoletin, and scoparone. Mechanistically, it has been shown to inhibit the PI3K/AKT signaling pathway, leading to apoptosis and anti-angiogenic effects in hepatocellular carcinoma cells. Additionally, it suppresses PPAR-γ expression to reduce lipid accumulation in obesity models and restores Glycine N-methyltransferase (GNMT) activity to mitigate electronegative LDL (L5)-induced vascular dysfunction. It remains in the preclinical stage of development with no commercial developer currently identified.

Other names: Artemisia capillaris ethyl acetate extractcapillary wormwood ethyl acetate extract

Targets

AKT (RAC-alpha serine/threonine-protein kinase)PPARG (Peroxisome proliferator-activated receptor gamma)PI3K (Phosphoinositide-3-kinase regulatory subunit 6)mTOR (Mammalian target of rapamycin kinase)GNMT (Glycine N-methyltransferase)

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