artemisone

Artemisone is a synthetic derivative of artemisinin, classified as a 10-amino-artemisinin compound. It has been developed for the treatment of malaria and has also shown efficacy against schistosomiasis, human cytomegalovirus (HCMV), and certain tumors[1][3][4]. Artemisone demonstrates superior in vitro and in vivo activity compared to other current artemisinins, with enhanced potency and reduced neurotoxicity[4][7]. Its mechanism of action involves the generation of free radicals through cleavage of its endoperoxide bridge by heme iron within infected erythrocytes, leading to damage of parasite proteins and death of the parasite[6][8]. Artemisone is under clinical investigation for uncomplicated falciparum malaria (e.g., NCT00936767) but faces challenges related to low aqueous solubility and bioavailability[2][4].

Other names

artemifone