Drug intelligence / Profile preview

arterolane + piperaquine + mefloquine

Development stage
Unknown
Lead developer
Sun Pharma
Modality
Small Molecules
Administration
Oral
01

Overview

A triple antimalarial combination therapy that combines arterolane (a synthetic ozonide antimalarial), piperaquine (a long-acting bisquinoline), and mefloquine. This combination was developed to reduce the risk of antimalarial resistance by combining a potent, rapidly cleared synthetic ozonide with two more slowly eliminated partner drugs. Clinical trials have shown it to be highly efficacious and safe for the treatment of uncomplicated falciparum malaria in children.

02

Targets

CALR (Calreticulin)Hemeβ-HematinPfHRP2 (Plasmodium falciparum histidine-rich protein II)PfMDR1 (Plasmodium falciparum multidrug resistance protein 1)

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