artichoke leaf extract

Artichoke leaf extract (ALE) is a botanical preparation derived from the leaves of *Cynara scolymus* (or *Cynara cardunculus*), containing bioactive polyphenols such as cynarin, chlorogenic acid, and flavonoids like luteolin. It is primarily utilized as a nutraceutical for its hepatoprotective, lipid-lowering, and antioxidant properties. The extract exerts its effects by inhibiting HMG-CoA reductase to lower cholesterol, stimulating bile production (choleretic effect), and activating the Nrf2/HO-1 antioxidant signaling pathway. ALE has been clinically investigated for the management of non-alcoholic fatty liver disease (NAFLD), metabolic dysfunction-associated steatotic liver disease (MASLD), and hypercholesterolemia. While widely available as a dietary supplement, its clinical efficacy in reducing LDL cholesterol has shown mixed results in various populations, leading to ongoing research into standardized formulations like Pycrinil and Altilix.

Brand names

PycrinilAltilix

Other names

Cynara scolymus extractCynara cardunculus extractArtichoke extract