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Artichoke Whole Phytocomplex Concentrate
- Development stage
- Unknown
- Lead developer
- OCOG
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Artichoke Whole Phytocomplex Concentrate (AWPC) is a standardized, freeze-dried extract of artichoke (Cynara scolymus) leaves developed by ABOCA and evaluated by the Ontario Clinical Oncology Group (OCOG). It is primarily investigated as a chemoprevention agent for malignant pleural mesothelioma in high-risk populations, such as individuals with asbestos-related lung or pleural disease. The extract is rich in bioactive compounds, including caffeoyl quinic acids, chlorogenic acid, and cynaropicrin. Its mechanism of action involves the induction of apoptosis, inhibition of cell proliferation, and reduction of cell invasion. In clinical trials, AWPC is monitored for its impact on biomarkers like serum mesothelin and specific microRNAs.
- Other names
- Artichoke WPCArtichoke extractCynara scolymus extract
02
Targets
Mesothelin
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