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ARUK2010489
- Development stage
- Unknown
- Lead developer
- University of Cambridge
01
Overview
ARUK2010489: sourced facts only. name: "Further development of this series also led to the discovery of ARUK2010489, a highly brain penetrant NUAK1 inhibitor (unbound brain/plasma ratio in mice (Kp,u,ub) of 2.29) that displays no CDK2 activity, applicable for CNS pharmacological studies." [PMID:41257021]; target: "Further development of this series also led to the discovery of ARUK2010489, a highly brain penetrant NUAK1 inhibitor (unbound brain/plasma ratio in mice (Kp,u,ub) of 2.29) that displays no CDK2 activity, applicable for CNS pharmacological studies." [PMID:41257021]; developer: "The ALBORADA Drug Discovery Institute, University of Cambridge, Island Research Building, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0AH, United Kingdom." [PMID:41257021]
02
Targets
NUAK1 (NUAK family SNF1-like kinase 1)
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