AS-254s

AS-254s: sourced facts only. name: "Extensive medicinal chemistry combined with structure-based design led to identification of 66s (AS-254s), a highly potent and selective ASH1L inhibitor (IC50 = 94 nM), representing substantially improved inhibitory activity over previously reported compounds targeting ASH1L." [PMID:39680643]; target: "Extensive medicinal chemistry combined with structure-based design led to identification of 66s (AS-254s), a highly potent and selective ASH1L inhibitor (IC50 = 94 nM), representing substantially improved inhibitory activity over previously reported compounds targeting ASH1L." [PMID:39680643]; developer: "Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States." [PMID:39680643]; stage: "Furthermore, 66s effectively blocked cell proliferation and induced apoptosis and differentiation in leukemia cells harboring MLL1 translocations." [PMID:39680643]