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AS15
- Development stage
- Phase 2
- Lead developer
- GSK
- Modality
- Liposomes → Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
AS15 is a vaccine adjuvant system developed to enhance the immune response to antigens in cancer vaccines. It contains CpG 7909 (a synthetic oligodeoxynucleotide that acts as a TLR9 agonist), monophosphoryl lipid A (a detoxified derivative of lipopolysaccharide acting as a TLR4 agonist), and QS-21 (a saponin immunostimulant). AS15 has been used in combination with recombinant tumor antigens such as recMAGE-A3 for antigen-specific immunotherapy in oncology, including prostate cancer and multiple myeloma. Its mechanism involves stimulating both innate and adaptive immunity, leading to enhanced antigen presentation and T-cell activation[2][3][5].
- Other names
- SB-AS15 adjuvantSB-AS-15 adjuvantSB-AS 15 adjuvant
02
Targets
CLR (C-type lectin receptors)TLR9 (Toll-like receptor 9)TLR4 (Toll-like receptor 4)
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