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AS1701 is a preclinical-stage biologic blocker developed by Zhongke Aishen Pharmaceutical (Amshenn) that targets the Rel immune checkpoint. Positioned as a next-generation successor to the company's AS1601 program, AS1701 is designed to inhibit Rel-mediated immunosuppression within the tumor microenvironment. The agent is intended for the treatment of solid tumors, either as a standalone therapy or in combination with PD-1 blockade to overcome resistance and improve clinical outcomes. It is currently in the efficacy exploration stage of development.
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