ASA-7

ASA-7 is an open-chain alkyl selenocyanate and organoselenium compound developed as a potential therapeutic for colorectal cancer (CRC) and other solid tumors. Identified through structure-activity relationship (SAR) studies of analogs of the lead compound AS-10, ASA-7 demonstrates growth inhibitory activity against various cancer cell lines, including pancreatic carcinoma (MiaPaCa2), lung carcinoma (H460), and colorectal carcinoma (HCT116, HT29), as well as FOLFOX-resistant colorectal cancer cells. While it shows similar in vitro potency to AS-10, ASA-7 exhibits higher toxicity in normal kidney (HEK293T) and colon (FHC) cell lines and is significantly less tolerable in vivo. Its mechanism of action involves acting as an acetyl donor for histone acetyltransferase (HAT), thereby inducing HAT activity and potentially modulating gene expression through histone acetylation.

Other names

open-chain alkyl selenocyanate