Drug intelligence / Profile preview

ASA1-OT10

Development stage
Preclinical
Modality
Peptide-Drug Conjugates → Peptide Conjugates → Peptides, Small Molecules
01

Overview

ASA1-OT10 is an experimental **4-aminosalicylic acid derived salicylanilide oligotuftsin conjugate** reported in the medicinal chemistry literature as part of a targeted anticancer research series. The name denotes an ASA1 small-molecule scaffold linked to the OT10 oligotuftsin carrier peptide, a neuropilin receptor ligand used to enhance cellular uptake and tissue penetration in glioblastoma models. In the available publication context, ASA1-OT10 was evaluated **in vitro** against U87 human glioblastoma cells, where compounds in this series reduced cell viability and were associated with induction of autophagy; however, the exact molecular target and any clinical development sponsor were not established in the source material.

02

Targets

NRP (Neuropilin)

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