Drug intelligence / Profile preview

asandeutertinib

Development stage
Phase 3
Lead developer
TYK Medicines
Modality
Small Molecules
Administration
Oral
01

Overview

Asandeutertinib is an investigational small molecule drug that acts as an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor with antineoplastic properties. It is being developed primarily for the treatment of non-small cell lung cancer (NSCLC), especially in patients harboring EGFR mutations. The drug irreversibly inhibits both wild-type and mutant forms of EGFR, including key resistance mutations such as T790M. Asandeutertinib is a deuterated analog related to osimertinib and demonstrates potent inhibition of EGFR signaling pathways involved in tumor growth and survival. The compound was initially developed by Changzhou Runnuo Biotechnology and has also been associated with TYK Medicines and Nanjing Diansu Biological Technology.

Other names
asandeutertinibum
02

Targets

EGFR exon 19del (Epidermal growth factor receptor exon 19 deletion mutant)EGFR T790M (Epidermal growth factor receptor T790M mutant)EGFR L858R (Epidermal growth factor receptor L858R mutant)

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