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ascorbic acid + ibuprofen
- Development stage
- Discontinued
- Lead developer
- Al-Azhar University
- Modality
- Small Molecules
- Administration
- Intravenous, Oral
01
Overview
This combination therapy consists of intravenous ascorbic acid (vitamin C) and oral ibuprofen, investigated for the treatment of hypoxic-ischemic encephalopathy (HIE) in neonates following perinatal asphyxia. Developed and studied by researchers at Al-Azhar University, the intervention aims to mitigate brain injury by targeting free oxygen radicals (via the antioxidant properties of ascorbic acid) and proinflammatory cytokines (via the anti-inflammatory properties of ibuprofen). Despite the theoretical neuroprotective benefits observed in animal models, a randomized controlled trial in term infants showed that early administration did not significantly improve mortality or neurodevelopmental outcomes at six months compared to placebo.
- Other names
- vitamin C + ibuprofenascorbic acid and ibuprofen combination therapy
02
Targets
PTGS2 (Prostaglandin-Endoperoxide Synthase 2)H2O2 (Hydrogen peroxide)PGHS-1 (Prostaglandin G/H Synthase 1)
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