Drug intelligence / Profile preview

ASHMI

Development stage
Phase 2
Lead developer
Sino-Lion
Administration
Oral
01

Overview

**ASHMI** is a proprietary three-herb anti-asthma botanical drug candidate developed for the treatment of asthma, particularly allergic asthma. It was studied under a United States FDA Investigational New Drug framework and in clinical trials led by Icahn School of Medicine at Mount Sinai. Published clinical context describes ASHMI as an oral capsule formulation manufactured by Sino-Lion Pharmaceutical and designed as a Chinese herbal medicine intervention with immunomodulatory anti-asthma activity rather than a defined single-molecule target mechanism. In a phase I randomized placebo-controlled dose-escalation study in adults with allergic asthma, ASHMI appeared safe and well tolerated, which supported subsequent phase II evaluation for asthma efficacy.

Brand names
ASHMI
Other names
anti-asthma herbal medicine intervention
02

Targets

IL-5 (Interleukin 5)IL-4 (Interleukin 4)PTGER4 (Prostaglandin E2 receptor EP4 subtype)NF-κBTNFA (Tumor necrosis factor alpha (soluble))PTGER2 (Prostaglandin E2 receptor EP2)

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