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ASM8
- Development stage
- Phase 2
- Lead developer
- Pharmaxis
- Modality
- Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Modified DNA Oligonucleotides → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Single-strand DNA → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Inhalation
01
Overview
ASM8 is an inhaled antisense oligonucleotide therapy developed for the treatment of moderate-to-severe asthma and allergic asthma. It consists of two modified antisense oligonucleotides that target the beta subunit (βc) shared by the interleukin-3 (IL-3), interleukin-5 (IL-5), and granulocyte-macrophage colony-stimulating factor (GM-CSF) receptors, as well as the chemokine receptor CCR3. By antagonizing these targets, ASM8 aims to reduce airway inflammation by inhibiting eosinophil recruitment and activity in asthmatic patients. Clinical studies demonstrated that inhaled ASM8 reduced sputum eosinophils and attenuated both early and late airway responses following allergen challenge in mild allergic asthmatics[1][4]. Despite promising results in phase 2 trials, development has been discontinued.
- Other names
- ASM 8ASM8ASM-8TPI-ASM8TPI-ASM-8TPI-ASM 8
02
Targets
CSF2RB (Cytokine receptor common subunit beta)CCR3 (C-C chemokine receptor type 3)
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