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ASO-control
- Development stage
- Preclinical
- Lead developer
- Duke University
- Modality
- Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Single-strand DNA → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Modified DNA Oligonucleotides → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Subcutaneous
01
Overview
ASO-control is an antisense oligonucleotide (ASO) designed to target the mRNA of green fluorescent protein (GFP). In the context of biomedical research, it serves as a negative control to distinguish the sequence-specific effects of a therapeutic ASO from the non-specific biological responses elicited by the oligonucleotide's chemical structure or the delivery method. In studies of atherosclerosis, ASO-control is used as a comparator to evaluate the efficacy of experimental ASOs, such as those targeting small nucleolar RNAs (snoRNAs), in reducing reactive oxygen species (ROS) and atherosclerotic plaque formation in mouse models.
- Other names
- ASO-GFPGFP-targeting antisense oligonucleotide
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