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asp1951
- Development stage
- Discontinued
- Lead developer
- Astellas Pharma
- Modality
- Vaccines & Immunotherapeutics, Classical Binding Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
ASP1951 is a human, high-affinity, tetravalent monospecific agonistic monoclonal antibody that targets the glucocorticoid-induced tumor necrosis factor receptor (GITR; also known as TNFRSF18). By binding to GITR on immune cells, ASP1951 acts as an agonist to stimulate the receptor and enhance anti-tumor immune responses. It was developed for use in advanced solid tumors both as a single agent and in combination with pembrolizumab. The drug was initially developed by Potenza Therapeutics and later by Astellas Pharma. Clinical development reached phase 1 trials but has since been discontinued for all indications[3][4][10].
02
Targets
TNFRSF18 (GITR)
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