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ASP2802 + MA-20
- Development stage
- Unknown
- Lead developer
- Astellas Pharma
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Recombinant Proteins and Enzymes
- Administration
- Intravenous
01
Overview
**ASP2802 + MA-20** is an experimental combination therapy consisting of ASP2802, a CAR-T cell therapy targeting CD20-positive B cells, and MA-20, an adjunctive protein intended to enhance the in vivo function or persistence of the CAR-T cells. ASP2802 is designed to recognize and bind to CD20, a surface antigen found on malignant B cells, facilitating their destruction by the engineered T cells. MA-20 is co-administered to improve the efficacy of the cellular therapy, although its precise mechanism of action is not fully detailed in the available sources[1][2][4]. The combination has been tested primarily in patients with CD20-positive B-cell lymphomas.
- Other names
- ASP2802 + MA-20
02
Targets
NKG2D-based Chimeric Antigen ReceptorCD20 (B-lymphocyte antigen CD20)
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