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ASP4396
- Development stage
- Unknown
- Lead developer
- Astellas Pharma
- Modality
- Nucleic Acid-Directed Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Intravenous
01
Overview
ASP4396 is a novel small molecule degrader targeting the KRAS G12D mutant protein. It is being developed by Astellas Pharma as a potential treatment for solid tumors harboring the KRAS G12D mutation, including metastatic and unresectable cancers. The drug works by promoting degradation of the mutant KRAS G12D protein, thereby inhibiting its oncogenic signaling pathway. ASP4396 is currently in Phase 1 clinical trials to evaluate its safety, tolerability, and to determine an appropriate dosing regimen in adults with advanced or metastatic solid tumors with confirmed KRAS G12D mutations[1][3][4][5][10].
- Other names
- ASP 4396ASP4396ASP-4396
02
Targets
KRASG12D (Kirsten rat sarcoma viral oncogene homolog (KRAS) G12D mutant)
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