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Aspergillus fumigatus skin prick solution
- Development stage
- Unknown
- Lead developer
- Wolwo Biotech
- Modality
- Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Percutaneous
01
Overview
Aspergillus fumigatus skin prick solution is a diagnostic allergen extract developed by Zhejiang Wolwo Bio-Pharmaceutical Co., Ltd. for the detection of type I hypersensitivity reactions. It is specifically designed for use in skin prick testing to identify sensitization to the fungus *Aspergillus fumigatus*, which is a common trigger for allergic conditions such as asthma, allergic rhinitis, and allergic bronchopulmonary aspergillosis (ABPA). The solution works by introducing fungal allergens into the skin; in sensitized individuals, these allergens cross-link specific IgE antibodies on the surface of mast cells, triggering the release of histamine and other mediators that result in a visible wheal-and-flare reaction. As of 2023, the product is undergoing Phase 1 dose-finding clinical trials in China to evaluate its safety and diagnostic performance.
- Other names
- Aspergillus fumigatus allergen extract
02
Targets
sIgG4 (Allergen-specific immunoglobulin G4)IgE (Immunoglobulin E)
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