aspirin + atorvastatin + clopidogrel

Trisorbagen is a fixed-dose combination (FDC) medication, often referred to as a 'polypill,' designed for the secondary prevention of cardiovascular events. It typically contains three active ingredients: **aspirin** (an antiplatelet agent), **clopidogrel** (a P2Y12 receptor antagonist), and **atorvastatin** (an HMG-CoA reductase inhibitor). Aspirin works by irreversibly inhibiting cyclooxygenase-1 (COX-1), thereby reducing the production of thromboxane A2 and preventing platelet aggregation. Clopidogrel provides a complementary antiplatelet effect by blocking the adenosine diphosphate (ADP) receptor on platelet membranes. Atorvastatin serves to lower low-density lipoprotein (LDL) cholesterol levels and stabilize atherosclerotic plaques. This combination is primarily indicated for patients with established coronary artery disease, particularly those who have undergone percutaneous coronary intervention (PCI) or have a history of myocardial infarction, to simplify treatment regimens and improve medication adherence.

Brand names

Trisorbagen

Other names

aspirin + atorvastatin + clopidogrel combination