aspirin + celecoxib

Aspirin + celecoxib is a combination of two small molecule drugs, each with distinct but sometimes overlapping mechanisms of action. Aspirin (acetylsalicylic acid) is an irreversible inhibitor of cyclooxygenase-1 (COX-1), leading to reduced synthesis of thromboxane A2 and thus inhibiting platelet aggregation; it also inhibits cyclooxygenase-2 (COX-2) at higher doses, providing anti-inflammatory and analgesic effects. Celecoxib is a selective COX-2 inhibitor that reduces the formation of prostaglandins involved in pain and inflammation, with less effect on COX-1 than traditional NSAIDs. The combination has been studied for synergistic effects in cancer therapy—particularly non-small cell lung cancer—where it may enhance apoptosis, arrest the cell cycle, inhibit migration/invasion via MMP inhibition, and modulate ERK-MAPK signaling pathways[5]. However, celecoxib can attenuate the antiplatelet effect of low-dose aspirin by competing for COX-1 binding[1]. Both drugs are widely used individually for pain relief, inflammation reduction (arthritis), cardiovascular protection (aspirin), and certain cancers.

Brand names

Celebrex + Aspirin