Drug intelligence / Profile preview

aspirin + chinese herbs

Development stage
Preclinical
Lead developer
Bayer
Modality
Implantable Devices → Device-based Delivery → Drug Delivery Systems, Small Molecules, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Inhalation Devices → Device-based Delivery → Drug Delivery Systems
Administration
Oral
01

Overview

Aspirin + Chinese herbs refers to the concurrent use or combination therapy of aspirin, a widely used antiplatelet and anti-inflammatory pharmaceutical, with various traditional Chinese herbal medicines. This combination is primarily explored for cardiovascular indications such as atherosclerotic cardiovascular diseases and for addressing aspirin resistance—a phenomenon where patients have reduced response to standard aspirin therapy. Commonly studied Chinese herbs in this context include danshen (Salvia miltiorrhiza), ginkgo biloba, Panax ginseng, Chuanxiong (Rhizoma Chuanxiong), Yan Hu Suo (Corydalis yanhusuo), and others that are believed to promote blood circulation and inhibit platelet aggregation. The mechanism of action involves both pharmacodynamic interactions—such as additive or synergistic inhibition of platelet aggregation—and pharmacokinetic interactions that may alter the metabolism or efficacy of aspirin. While some clinical studies suggest potential benefits in reducing platelet aggregation rates when combining these therapies, evidence quality is variable and safety concerns exist regarding increased bleeding risk due to overlapping antiplatelet effects[1][2][3][4].

02

Targets

P2Y12 (Purinergic P2Y12 receptor)PGHS-1 (Prostaglandin G/H Synthase 1)PDE (Phosphodiesterase family)

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