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aspirin + clopidogrel + ticagrelor + atorvastatin + rosuvastatin + metoprolol-The First Affiliated Hospital of Dalian Medical University
- Development stage
- Unknown
- Lead developer
- The First Affiliated Hospital of Dalian Medical University
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
This combination represents a regimen of optimal medical therapy (OMT) used in the treatment of coronary artery disease, specifically for patients with single coronary total occlusion (CTO) lesions. It includes dual antiplatelet therapy (aspirin combined with either clopidogrel or ticagrelor), lipid-lowering statins (atorvastatin or rosuvastatin), and a beta-blocker (metoprolol, often referred to by the brand name Betaloc). The regimen is designed to reduce the risk of major adverse cardiovascular events (MACE), stabilize plaques, and manage symptoms in patients undergoing or being considered for percutaneous coronary intervention (PCI). This specific protocol is being studied by The First Affiliated Hospital of Dalian Medical University in the SOS-comedy trial to investigate the effect of PCI on myocardial viability compared to OMT alone.
- Other names
- Optimal Medical TherapyOMTaspirin + clopidogrel + ticagrelor + atorvastatin + rosuvastatin + betaloc
02
Targets
VPAC (VIP receptor family)ADRB1 (β1)PGHS-1 (Prostaglandin G/H Synthase 1)HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)P2Y12 (Purinergic P2Y12 receptor)
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