aspirin + heparin

Aspirin + heparin is a combination therapy consisting of two pharmacologically distinct agents used together primarily for their additive antithrombotic effects. Aspirin (acetylsalicylic acid) is a non-steroidal anti-inflammatory drug (NSAID) that irreversibly inhibits cyclooxygenase-1 (COX-1), thereby suppressing thromboxane A2 production and inhibiting platelet aggregation. Heparin is an anticoagulant that potentiates the activity of antithrombin III, leading to inhibition of thrombin (factor IIa) and factor Xa, thus preventing fibrin clot formation. The combination is commonly used in clinical settings such as acute coronary syndromes, unstable angina, myocardial infarction, percutaneous coronary interventions, and in certain obstetric indications like antiphospholipid syndrome with recurrent pregnancy loss or severe preeclampsia[1][2][4][5]. While the combination enhances efficacy in reducing thrombotic events compared to either agent alone[2][5], it also increases bleeding risk and should be used under careful medical supervision[3][7].

Other names

acetylsalicylic acid + heparinASA + heparin