aspirin + oxycodone hydrochloride + oxycodone terephthalate

Aspirin + oxycodone hydrochloride + oxycodone terephthalate is an oral small-molecule analgesic combination historically marketed as **Percodan** by Endo Pharmaceuticals for the treatment of moderate to moderately severe pain. The specific legacy formulation contains 325 mg aspirin together with oxycodone provided as two salts, 4.5 mg oxycodone hydrochloride and 0.38 mg oxycodone terephthalate, in a tablet dosage form. Its analgesic effect combines the central opioid activity of oxycodone, a semisynthetic opioid agonist acting primarily at mu-opioid receptors and also kappa-opioid receptors in the central nervous system, with the peripheral anti-inflammatory and analgesic activity of aspirin, which inhibits prostaglandin synthesis through cyclooxygenase inhibition. This exact two-salt oxycodone formulation was later reformulated, with the oxycodone terephthalate component removed from newer Percodan products.

Brand names

Percodan

Other names

aspirin + oxycodone hydrochloride + oxycodone terephthalateoxycodone + aspirin