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aspirin + vitamin D
- Development stage
- Unknown
- Lead developer
- Louisiana State University Health Sciences Center
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Aspirin + vitamin D is a combination therapy investigated in the LEAD COVID-19 Phase 2 trial conducted by the Louisiana State University Health Sciences Center in New Orleans. The regimen consists of low-dose aspirin (81 mg daily) and high-dose vitamin D (50,000 IU weekly). Aspirin, a small molecule salicylate, acts as an irreversible inhibitor of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), providing anti-inflammatory and antiplatelet effects to mitigate COVID-19-associated coagulopathy (CAC). Vitamin D is included to address vitamin D insufficiency, which is hypothesized to contribute to the prothrombotic state in severe COVID-19. The primary goal of this early intervention is to reduce hospitalization rates in newly diagnosed outpatients.
- Other names
- aspirin-Louisiana State University Health Sciences Center in New Orleans-COVID-19LEAD COVID-19 interventionaspirin and vitamin D
02
Targets
PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)VDR (Vitamin D receptor)
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