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Aspirlose
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Intraperitoneal
01
Overview
Aspirlose is a novel ester conjugate synthesized by the chemical coupling of aspirin (acetylsalicylic acid) and the disaccharide trehalose. Developed by researchers at the Technion - Israel Institute of Technology and Rambam Health Care Campus, Aspirlose is designed to treat acute pancreatitis (AP). The compound leverages the anti-inflammatory and heparanase-inhibiting properties of aspirin combined with the pancreato-protective and autophagy-regulating effects of trehalose. In preclinical models of cerulein-induced acute pancreatitis, Aspirlose demonstrated superior efficacy in reducing pancreatic enzymes (amylase and lipase), tissue edema, and inflammatory biomarkers compared to either aspirin or trehalose administered alone.
- Other names
- Aspirin-Trehalose conjugateAspirin-Trehalose conjugates
02
Targets
PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)HPSE (Heparanase)
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