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ASPRIHALE
- Development stage
- Unknown
- Lead developer
- Philip Morris International
- Modality
- Small Molecules
- Administration
- Inhalation
01
Overview
ASPRIHALE is a proprietary dry powder inhalation formulation of acetylsalicylic acid (aspirin) delivered via a portable dry powder inhaler (DPI). It is specifically designed for the emergency treatment of suspected acute myocardial infarction (heart attack). Developed by OtiTopic and later acquired by Philip Morris International, this drug-device combination product is intended for patient self-administration at the onset of symptoms. By utilizing the pulmonary route, ASPRIHALE bypasses the gastrointestinal tract, achieving complete inhibition of platelet aggregation in approximately 2 minutes—significantly faster than the 20-30 minutes required for standard chewable aspirin. The drug works by irreversibly inhibiting cyclooxygenase-1 (COX-1), which prevents the synthesis of thromboxane A2 and subsequent platelet-mediated clot formation.
- Brand names
- ASPRIHALE
- Other names
- acetylsalicylic acidaspirininhaled aspirin
02
Targets
PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)
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