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**Astaxanthin + tocotrienol + zinc** is a dietary supplement formulation containing 12 mg astaxanthin, 10 mg tocotrienol (a form of vitamin E), and 6 mg zinc per daily dose[1][4]. This combination is designed to provide synergistic antioxidant and anti-inflammatory effects. Astaxanthin is a potent carotenoid antioxidant derived from microalgae, tocotrienol enhances lipid-based antioxidative activity and supports astaxanthin's effects, while zinc stabilizes antioxidant enzyme activity (notably SOD1). This formulation has been tested in elderly subjects in clinical trials and demonstrated significant improvements in muscle strength, endurance, and muscle cross-sectional area when paired with exercise. The supplement targets oxidative stress and inflammation, which can contribute to age-related muscle decline, mobility loss, and reduced endurance[1][4]. Mechanistically, astaxanthin acts at cellular membranes to scavenge ROS, tocotrienol counteracts lipid peroxidation and modulates antioxidative pathways, while zinc is a cofactor for numerous antioxidant enzymes and supports immunological and healing processes[1][2]. Primary indications studied: improving muscle strength, endurance, mobility, and potentially age-related sarcopenia and dynapenia[1]. Developer: Astamed
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